What question did this study set out to answer?

To review the mechanisms driving antimicrobial resistance in cystic fibrosis, evaluate current therapeutic and diagnostic limitations, and identify future directions for stewardship and molecular diagnostics.

January 20, 2023AntibioticsOpen Access

Antibiotic Resistance in Patients with Cystic Fibrosis: Past, Present, and Future

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To review the mechanisms driving antimicrobial resistance in cystic fibrosis, evaluate current therapeutic and diagnostic limitations, and identify future directions for stewardship and molecular diagnostics.
Synthesized literature on pathogen adaptations, such as biofilm formation, and pharmacokinetic barriers that alter lung parenchyma penetration during pulmonary exacerbations.
Evaluated the diagnostic limitations of conventional culture-based susceptibility testing relative to the complex lung microenvironment.
Reviewed clinical applications of emerging molecular diagnostics, including metagenomic sequencing and next-generation transcriptomics, alongside antimicrobial stewardship programs.
Conventional culture-based susceptibility testing inadequately models in vivo physiological barriers, altered pharmacokinetics, and pathogen biofilm dynamics in cystic fibrosis lungs.
Stagnant antibiotic development pipelines necessitate targeting specific microbial resistance mechanisms through high-resolution molecular tools like transcriptomics and metagenomics.
Active antimicrobial stewardship and routine monitoring of antibiotic utilization are essential to mitigate persistent infections and suppress emerging resistant strains.

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Implication

Review details antimicrobial resistance drivers and diagnostic challenges in cystic fibrosis, highlighting the need for molecular diagnostics and rigorous antimicrobial stewardship.

Cite This Study

Perikleous et al. (2023) studied this question.

synapsesocial.com/papers/6a95ab7bd28cc96cd6ffa8c3 https://doi.org/10.3390/antibiotics12020217

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Implication

Review details antimicrobial resistance drivers and diagnostic challenges in cystic fibrosis, highlighting the need for molecular diagnostics and rigorous antimicrobial stewardship.

Antibiotic Resistance in Patients with Cystic Fibrosis: Past, Present, and Future

Key Points

Discussion

Implication

Cite This Study

Antibiotic Resistance in Patients with Cystic Fibrosis: Past, Present, and Future

Key Points

Discussion

Implication

Cite This Study