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September 5, 2009Journal of Biological ChemistryOpen Access

Mechanism of the Internal Ribosome Entry Site-mediated Translation of Serine Hydroxymethyltransferase 1

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Population

In vitro translation extracts and SHMT1 transcript models

Comparison

Depletion of CUGBP1 or deletion of CUGBP1… vs Polyadenylylated biscistronic mRNAs

Design

Preclinical

Authors

JFJennifer T. FoxNational Cancer InstitutePSPatrick J. StoverFlorida State University

Discussion

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Implication

No immediate clinical impact; extends IRES mechanisms to poly(A)-independent translation in metabolic genes.

Structured PICO

P
Population
In vitro translation extracts and SHMT1 transcript models
I
Intervention
Depletion of CUGBP1 or deletion of CUGBP1 binding site on the 3'-UTR of the SHMT1 transcript
C
Comparator
Polyadenylylated biscistronic mRNAs
O
Outcome
IRES activity and translational efficiencysurrogate

This study identifies the first cellular IRES that is poly(A) tail-independent, utilizing hnRNP H2 and CUGBP1 for mRNA circularization and translation of SHMT1.

Cite This Study

Fox et al. (2009) studied this question.

synapsesocial.com/papers/6a95ac008cecc6dab090f80dhttps://doi.org/10.1074/jbc.m109.035576
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficiency of reinitiation of translation on human immunodeficiency virus type 1 mRNAs is determined by the length of the upstream open reading frame and by intercistronic distance1995 · 188 citations
  2. 2The requirement for eukaryotic initiation factor 4A (eIF4A) in translation is in direct proportion to the degree of mRNA 5′ secondary structure2001 · 476 citations
  3. 3The 3' Untranslated Region of Satellite Tobacco Necrosis Virus RNA Stimulates Translation in Vitro1993 · 104 citations
  4. 4Translation initiation factor eIF4G mediates <i>in vitro</i> poly(A) tail-dependent translation1997 · 322 citations
  5. 5Cytoplasmic Serine Hydroxymethyltransferase Mediates Competition between Folate-dependent Deoxyribonucleotide andS-Adenosylmethionine Biosyntheses2002 · 268 citations