Key result
Left ventricular systolic and diastolic dysfunction, including reduced ejection fraction and stroke volume index, were significantly associated with the progression of arterial hypertension in patients with type 2 diabetes and obesity.
Cohort (n=48)
No
In patients with arterial hypertension, type 2 diabetes, and obesity, echocardiographic parameters of systolic and diastolic dysfunction correlate with disease progression at 6 months.
The aim of the study was to analyze the influence of systolic and diastolic function of the left ventricle on arterial hypertension (AH) progression in patients with diabetes mellitus (DM) and obesity.Material and methods. There were 48 patients with AH, DM2T and obesity under observation. The patients were divided into 2 groups: the first group consisted of 23 patients without progression of the disease, the second group ― 25 patients who had progression of the disease. Electrocardiography in the standard 12 leads was used; on an ultrasonic machine "Philips HD11XE" (USA) by an ECHO-pulse method with an ultrasound frequency of 7.5 MHz.Results. The study showed that EDV and EDD did not reveal significant interrelations (p ≥ 0.05) with AH progression. The relatively low (≤ 25,0 ml/m2) values of the stroke volume index turned out to be specific for patients with AH progression, as they were defined only among them (12.2%) and were not determined among patients without progression (0%, p ≤ 0,05). Higher values of stroke volume (≥ 101 ml) were specific for the group without disease progression and were diagnosed in 24,4% of patients in this group and 6 times less frequently (p≤ 0,001) among patients with AH progression. Conclusions. Left ventricle ejection fraction, stroke volume index, left ventricle stroke volume, the left ventricle shortening degree, the ratio of peak velocity of early diastolic to late transmitral flow and diastolic time had negative correlation with arterial hypertension progression. The values of end-systolic volume, end-systolic dimension, LAD left atrium diameter, left ventricle mass index, interventricular septal thickness, left ventricular posterior wall, peak velocity of early diastolic transmitral flow, peak velocity of late transmitral flow, isovolumic relaxation time had positive correlation. Disturbance of diastolic function is a significant factor of hypertension progression in patients with diabetes type 2 and obesity.
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Борис Олексійович Шелест (2018) conducted a cohort in Arterial hypertension with type 2 diabetes mellitus and obesity (n=48). Left ventricular systolic and diastolic dysfunction vs. Preserved left ventricular function was evaluated on Progression of arterial hypertension (appearance or increase of microalbuminuria and increased carotid intima-media thickness). Left ventricular systolic and diastolic dysfunction, including reduced ejection fraction and stroke volume index, were significantly associated with the progression of arterial hypertension in patients with type 2 diabetes and obesity.
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