Key result
Hemodialysis significantly increased QTc dispersion from 61 msec predialysis to 86 msec postdialysis (p<0.001), which correlated with changes in serum potassium, calcium, and pH levels.
Why the study?
Does hemodialysis affect QTc interval and QTc dispersion in patients with end-stage renal failure?
Population
40 patients with end-stage renal failure on long-term hemodialysis (22 men, 18 women, mean age 44 years)
Comparison
Hemodialysis (evaluation of postdialysis phase) vs Normal subjects and predialysis values
Design
Cohort
Follow-up
Immediate postdialysis
Authors
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Raises arrhythmia vigilance during hemodialysis; leaves open whether electrolyte protocols mitigate QTc dispersion in ESRD.
Observational (n=40)
Does hemodialysis affect QTc interval and QTc dispersion in patients with end-stage renal failure?
Absolute Event Rate: 86% vs 61%
p-value: p=<0.001
Hemodialysis significantly increases QTc interval and dispersion in end-stage renal failure patients, which correlates with rapid shifts in serum electrolytes and acid-base status.
Yetkın et al. (2000) conducted an observational in End-stage renal failure (n=40). Hemodialysis vs. Predialysis baseline was evaluated on QTc dispersion (p=<0.001). Hemodialysis significantly increased QTc dispersion from 61 msec predialysis to 86 msec postdialysis (p<0.001), which correlated with changes in serum potassium, calcium, and pH levels.
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