ras oncogene products (for review, see Barbacid 1987) are of interest for at least two reasons: First, the most commonly found oncogenes isolated from human tumors or transformed human cell lines belong to the ras gene family (for a survey, see Nishimura and Sekiya 1987); second, ras gene products are thought to belong to the family of signal transducer proteins, G proteins (for review, see Stryer and Bourne 1986; Gilman 1987; Neer and Clapham 1988). In the human genome, there are three distinct cellular ras genes: c-Ha-ras, c-Ki-ras, and N-ras. Proteins encoded by these genes, p21 proteins, have a molecular weight of 21,000 with 188 or 189 amino acid residues, bind GDP/GTP (Scolnick et al. 1979), and have practically identical amino acid sequences, with the exception of the carboxy-terminal 25 residues. The difference between the normal ras proto-oncogenes and the activated (transforming) ras oncogenes is usually a single base change...
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Kim et al. (1988) studied this question.