Key result
A high-fat diet for 20 weeks induced obesity in mice and led to a 2-fold increase in basal mitochondrial respiration in brown adipose tissue, alongside increased inflammation and oxidative stress.
Absolute Event Rate: 6.92% vs 3.12%
p-value: p=0.03
Obesity induced by a high-fat diet in mice leads to increased mitochondrial activity, inflammation, and oxidative damage in brown adipose tissue.
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Does not support clinical changes in obesity care; leaves open translational relevance of BAT mitochondrial changes to humans.
Alcalá et al. (2017) studied Obesity. High-fat diet vs. Normal chow diet (10% Kcal fat) was evaluated on Basal oxygen consumption rate (OCR) in brown adipose tissue (pmol/min × μg prot) (p=0.03). A high-fat diet for 20 weeks induced obesity in mice and led to a 2-fold increase in basal mitochondrial respiration in brown adipose tissue, alongside increased inflammation and oxidative stress.
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