Key result
The renin-angiotensin system maintains blood pressure via vasoconstriction and renal sodium absorption, despite the paradoxical existence of low-renin hypertensive states.
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Design
Review
Supports RAS blockade in hypertension; leaves open mechanisms of low-renin states for targeted research.
The classical role of the renin-angiotensin system (RAS) has been to serve as a vasoconstrictor and to facilitate renal sodium absorption, serving to maintain BP. A puzzling aspect of the RAS, however, has been the existence of low-renin hypertensive states, defined as a low plasma renin activity (
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Ruth Campbell (2004) studied this question. The renin-angiotensin system maintains blood pressure via vasoconstriction and renal sodium absorption, despite the paradoxical existence of low-renin hypertensive states.
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