Key result
Height was identified as the only independent predictor of pulse wave velocity in healthy prepubertal Angolan children (p=0.002), enabling the development of reference values.
Cross-Sectional (n=157)
No
Effect estimate: β=0.018
p-value: p=0.002
Height is the primary independent predictor of pulse wave velocity in prepubertal black children, allowing for the creation of height-based reference percentiles for this population.
May guide PWV assessment in prepubertal children; leaves open prospective validation and generalizability.
Carotid-femoral pulse wave velocity (PWV) has been used as the gold standard method to estimate arterial stiffness. However, its use in clinical practice is still limited because reference values for specific groups, such as black children, remain unknown. The authors aimed to investigate predictors and to propose preliminary reference values of PWV in this population. Prepubertal schoolchildren (N=157; mean age, 9.36±1.41 year) from Luanda (Angola) with normal blood pressure values and without obesity were included. Mean PWV was 5.73±0.68 m/s, with no difference between the sexes. Univariate regression analysis showed a significant (P<.05) positive correlation between PWV and height, age, body weight, lean body weight, and blood pressure. In multivariate analysis, however, only height remained an independent predictor of PWV [PWV=0.018×height (cm)+3.230]. Curves of PWV percentiles as a function of height are proposed, thus identifying normal PWV in black children.
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Silva et al. (2015) conducted a cross-sectional in Healthy prepubertal children (n=157). Height was evaluated on Predictors of carotid-femoral pulse wave velocity (β=0.018, p=0.002). Height was identified as the only independent predictor of pulse wave velocity in healthy prepubertal Angolan children (p=0.002), enabling the development of reference values.
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