The effectiveness of long term uricosuric therapy was evaluated in sixty‐four patients with primary gout. Serum uric acid was reduced to normal in half the patients; the majority manifested a urate diuresis. In seventeen of fifty patients with tophi, these lesions decreased in size. Acute gouty attacks were reduced to less than one per year in forty‐five, patients; the chronic symptoms present in fifty‐one patients improved in forty., Effectiveness of therapy was categorized as good, moderate, and poor, with examples of illustrative cases.
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Thompson et al. (1962) studied this question.
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