What question did this study set out to answer?

To evaluate the efficacy, survival outcomes, and safety of combined laryngeal conservation surgery and radiation therapy for high-risk laryngeal and hypopharyngeal carcinomas.

November 1, 1981Otolaryngology

Combined Laryngeal Conservation Surgery and Irradiation: Can We Expand the Indications for Conservation Therapy?

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Authors

HGHelmuth GoepfertSidney Kimmel Cancer Center RLRobert D. LindbergLeiden University Medical Center RIRichard H. Iesse

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Implication

Cohort study reports a 56% survival rate in laryngeal and hypopharyngeal cancer treated with conservation surgery and radiation, indicating expanded feasibility for organ-sparing therapy.

Key Points

To evaluate the efficacy, survival outcomes, and safety of combined laryngeal conservation surgery and radiation therapy for high-risk laryngeal and hypopharyngeal carcinomas.
Analyzed 39 patients (median age 60 years) with carcinoma of the supraglottic larynx (N=16), vocal cord (N=4), or hypopharyngeal wall and pyriform sinus (N=19).
Administered combined conservation surgery and radiotherapy, delivered postoperatively in 33 patients and preoperatively in 6 patients due to high risk of recurrence above the clavicles.
Followed 38 patients who completed treatment for a median duration of 48 months (range: 1.5 to 6 years).
Achieved an absolute survival rate of 56% and a determinant survival rate of 63% among patients completing therapy.
Identified long-term complications in 6 patients, which led to 2 fatal cases of aspiration pneumonia.

Cite This Study

Goepfert et al. (1981) studied this question.

synapsesocial.com/papers/6a95b6754a90f9fdf309e18a https://doi.org/10.1177/019459988108900619

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Implication

Cohort study reports a 56% survival rate in laryngeal and hypopharyngeal cancer treated with conservation surgery and radiation, indicating expanded feasibility for organ-sparing therapy.

Combined Laryngeal Conservation Surgery and Irradiation: Can We Expand the Indications for Conservation Therapy?

Discussion

Member takes

Implication

Key Points

Cite This Study

Combined Laryngeal Conservation Surgery and Irradiation: Can We Expand the Indications for Conservation Therapy?

Discussion

Member takes

Implication

Key Points

Cite This Study

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