What question did this study set out to answer?

Investigate the synthetic scope, reaction parameters, and structural utility of combining cycloaddition with radical cyclization in a tandem sequence.

October 1, 1989The Journal of Organic Chemistry

Scope of tandem cycloadditon/radical cyclization methodology

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Authors

TGTirthankar GhoshRamakrishna Mission Vivekananda Educational and Research Institute HHHarold HartGifu Pharmaceutical University

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Implication

Methodological study demonstrates the synthetic scope of coupled cycloaddition and radical cyclization, highlighting efficient pathways for constructing complex polycyclic architectures.

Key Points

Investigate the synthetic scope, reaction parameters, and structural utility of combining cycloaddition with radical cyclization in a tandem sequence.
Evaluated sequential reactions coupling cycloaddition steps with subsequent radical cyclization cascades.
Tested diverse structural precursors to define functional group compatibility and synthetic constraints.
Demonstrated a robust synthetic sequence connecting cycloaddition with radical cyclization to assemble multi-ring frameworks.
Showed qualitatively efficient construction of complex polycyclic carbon skeletons directly from simpler starting materials.

Cite This Study

Ghosh et al. (1989) studied this question.

synapsesocial.com/papers/6a95b73c9bd2cd984133308b https://doi.org/10.1021/jo00282a022

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Implication

Methodological study demonstrates the synthetic scope of coupled cycloaddition and radical cyclization, highlighting efficient pathways for constructing complex polycyclic architectures.

Scope of tandem cycloadditon/radical cyclization methodology

Discussion

Member takes

Implication

Key Points

Cite This Study

Scope of tandem cycloadditon/radical cyclization methodology

Discussion

Member takes

Implication

Key Points

Cite This Study

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