Key result
Neonatal circulatory transition causes significant left ventricular distortion at end-systole due to septal flattening that resolves by day 5, making standard M-mode echocardiography unreliable.
Why the study?
How do global and regional left ventricular mechanics change in normal newborns during the first days of life?
Population
Normal newborns during the first days of life, and a control group of normal infants and young children.
Comparison
Sequential two-dimensional echocardiographic… vs Control group of normal infants and young…
Design
Cohort
Follow-up
5 days
Authors
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M-mode LV assessment may be unreliable in newborns before day 5; leaves open validation of alternative methods before clinical adoption.
Observational
How do global and regional left ventricular mechanics change in normal newborns during the first days of life?
Standard M-mode echocardiographic assessment of left ventricular function is unreliable in newborns before day 4 due to transient septal flattening and altered regional wall motion.
Rein et al. (1987) conducted an observational in Normal newborns. Neonatal circulatory transition vs. Normal infants and young children was evaluated on Global and regional left ventricular wall motion. Neonatal circulatory transition causes significant left ventricular distortion at end-systole due to septal flattening that resolves by day 5, making standard M-mode echocardiography unreliable.
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