Delivery of oxygen to cells is critical to biochemical and metabolic processes and is particularly important during conditions of illness and recovery. However, accurate measurement of perfusion and tissue oxygen tension, determinants of cellular oxygen supply, has been problematic. Technologic advancements offer promise for the assessment of these significant variables. Instruments utilizing polarographic electrodes have been commonly used for the measurement of tissue oxygen tension. Recently, optical fluorescence has been employed to measure the partial pressure of oxygen. These predominant methods for determining tissue oxygen tension are described and applications for research are discussed.
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JoAnne D. Whitney (1990) studied this question.
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