Key result
Nuclear envelope myopathies present with variable clinical features, and careful management of associated cardiac symptoms, including lethal arrhythmia and cardiomyopathy, is critical for prognosis.
Why the study?
Nuclear envelope myopathies have variable onset and features, but managing associated cardiac symptoms such as lethal arrhythmia and cardiomyopathy is critical for prognosis.
Careful management of cardiac symptoms, including lethal arrhythmia and cardiomyopathy, is critical for the prognosis of patients with nuclear envelope myopathies.
Nuclear envelope (NE) is a term of the structure surrounding each nucleus of the cell and has many important functions including maintaining chromatin organization. Mutations in the genes encoding NE proteins are known to cause several diseases including myopathies. The age at onset and clinical features of NE myopathy are quite variable, but careful management of associated cardiac symptoms including lethal arrhythmia and cardiomyopathy is critical for the prognosis. In this review, clinical characteristics of NE myopathies together with recent advances of their management is described.
No takes yet. Share an insight, caveat, or question.
Yukiko Hayashi (2022) conducted a review in Nuclear envelope myopathy. Nuclear envelope myopathies present with variable clinical features, and careful management of associated cardiac symptoms, including lethal arrhythmia and cardiomyopathy, is critical for prognosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: