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Sterols like cholesterol, ergosterol, ergocalciferol and stigmasterol can antagonize various reactions of the polypeptide antibiotic mycobacillin on sensitive cells of Aspergillus niger, e. g. growth inhibition, agglutination and release of ultraviolet-absorbing compounds from the cells. Among the lipids tested viz. lecithin, sphingomyelin and cephalin, only lecithin is able to antagonize these antifungal reactions of mycobacillin. The growth-inhibiting property of the antibiotic on A. niger is antagonized by intracellular sterols and lipids isolated from the same sensitive organism. The intracellular antagonists have been characterized mainly as cholesterol and lecithin.
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Halder et al. (1971) studied this question.
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