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September 1, 2006Plastic & Reconstructive Surgery

Commercially Available Demineralized Bone Matrix Compositions to Regenerate Calvarial Critical-Sized Bone Defects

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Authors

TATahsin Oğuz AcartürkUniversity of Pittsburgh JHJeffrey O. HollingerCarnegie Mellon University

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Implication

Comparative animal study demonstrates differential bone healing across demineralized bone matrix formulations in rat skull defects, highlighting the crucial impact of carrier composition.

Key Points

To quantify and compare bone regeneration produced by commercially available demineralized bone matrix formulations in critical-sized calvarial defects.
Tested seven commercial preparations—Allomatrix, DBX, DBX with poly(DL-lactide) mesh, Dynagraft, Grafton, Regenafil, and carrier-free human demineralized bone matrix—alongside poly(DL-lactide) mesh alone in 8-mm calvarial defects in athymic rats.
Recovered defect tissues at 2, 4, and 8 weeks post-implantation for undecalcified histology and histomorphometry, analyzing differences using ANOVA and Fisher's protected least significant difference test (significance at p ≤ 0.05).
DBX, DBX plus poly(DL-lactide) mesh, Grafton, and carrier-free demineralized bone matrix stimulated significantly greater bone formation.
Allomatrix, Dynagraft, Regenafil, and poly(DL-lactide) mesh alone yielded significantly lower bone formation across the evaluation periods.

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Acartürk et al. (2006) studied this question.

synapsesocial.com/papers/6a95bafbbfbc970cab48f335 https://doi.org/10.1097/01.prs.0000232385.81219.87

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Implication

Comparative animal study demonstrates differential bone healing across demineralized bone matrix formulations in rat skull defects, highlighting the crucial impact of carrier composition.

Commercially Available Demineralized Bone Matrix Compositions to Regenerate Calvarial Critical-Sized Bone Defects

Discussion

Member takes

Implication

Key Points

Cite This Study

Commercially Available Demineralized Bone Matrix Compositions to Regenerate Calvarial Critical-Sized Bone Defects

Discussion

Member takes

Implication

Key Points

Cite This Study

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