What question did this study set out to answer?

To evaluate the safety, feasibility, and therapeutic antitumor effects of radio frequency hyperthermia in patients with advanced, deep-seated sarcomas.

January 1, 1981Journal of Surgical Oncology

Radio frequency hyperthermia of advanced human sarcomas

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Authors

FSF. Kristian StormUniversity of Wisconsin–Madison RERobert S. ElliottConcord Hospital WHWilliam HarrisonNorthwestern University

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Implication

Clinical study demonstrates effective deep tumor heating and necrosis in advanced sarcomas, indicating the therapeutic viability of radio frequency hyperthermia.

Key Points

To evaluate the safety, feasibility, and therapeutic antitumor effects of radio frequency hyperthermia in patients with advanced, deep-seated sarcomas.
Administered localized radio frequency hyperthermia using a device designed to heat deep tissues without causing surface injury in 12 patients (N=12) with advanced sarcomas.
Evaluated tumors located in the abdomen (n=7), chest wall (n=2), proximal extremity (n=2), and neck (n=1) across histologies including liposarcoma (n=3), rhabdomyosarcoma (n=2), leiomyosarcoma (n=2), neurofibrosarcoma (n=2), mesothelioma (n=1), undifferentiated sarcoma (n=1), and osteosarcoma (n=1).
Intratumoral temperatures reached ≥42°C in 12/12 patients (100%), ≥45°C in 9/12 patients (75%), and ≥50°C in 6/12 patients (50%), with virtually no normal tissue injury.
Treatment protocols of one to five weekly sessions at ≥50°C or ten daily sessions at ≥45°C produced significant tumor necrosis and pain relief in select patients.

Cite This Study

Storm et al. (1981) studied this question.

synapsesocial.com/papers/6a95bb09b3a30ccf5d319442 https://doi.org/10.1002/jso.2930170202

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Implication

Clinical study demonstrates effective deep tumor heating and necrosis in advanced sarcomas, indicating the therapeutic viability of radio frequency hyperthermia.

Radio frequency hyperthermia of advanced human sarcomas

Discussion

Member takes

Implication

Key Points

Cite This Study

Radio frequency hyperthermia of advanced human sarcomas

Discussion

Member takes

Implication

Key Points

Cite This Study

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