Key result
Methohexital prolonged mean motor seizure duration compared with propofol (weighted mean difference 9.06 seconds; 95% CI 5.72-12.40) during electroconvulsive therapy.
Why the study?
Do different general anesthetic induction agents affect seizure duration and recovery times in adults receiving electroconvulsive therapy?
Population
Adults receiving electroconvulsive therapy (ECT) (41 randomized trials)
Comparison
General anesthetic induction agents vs Alternative general anesthetic induction agents
Design
Meta-analysis
Authors
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Methohexital may be favored over propofol when longer seizures are targeted in ECT; meta-analysis confirms induction-agent effects on seizure parameters.
Systematic Review
Do different general anesthetic induction agents affect seizure duration and recovery times in adults receiving electroconvulsive therapy?
Mean Difference: 9.06 (95% CI 5.72–12.4)
Methohexital or the addition of a short-acting opioid to methohexital or propofol can be used to prolong seizure length during ECT, though all available induction agents are considered appropriate.
Hooten et al. (2008) conducted a systematic review in Electroconvulsive therapy. Methohexital vs. Propofol was evaluated on mean motor seizure duration (weighted mean difference 9.06 seconds, 95% CI 5.72-12.40). Methohexital prolonged mean motor seizure duration compared with propofol (weighted mean difference 9.06 seconds; 95% CI 5.72-12.40) during electroconvulsive therapy.
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