Key result
Wild bitter melon leaf extract (TCD fraction) inhibited adipocyte hypertrophy and diminished hepatic lipid accumulation and lipogenic markers in a zebrafish model of diet-induced dyslipidemia.
Why the study?
Aberrant lipid metabolism is linked to various health disorders, and wild bitter melon (WBM) may regulate lipid synthesis and accumulation, but its effects required validation.
Does wild bitter melon leaf extract reduce lipid accumulation in preclinical models of dyslipidemia?
Does wild bitter melon leaf extract reduce lipid accumulation in preclinical models of dyslipidemia?
Wild bitter melon leaf extract (TCD fraction) reduces lipid accumulation and lipogenic markers in preclinical models of dyslipidemia, suggesting potential therapeutic applications.
Hypothesis-generating for WBM in dyslipidemia models; clinical translation remains untested.
Aberrant lipid metabolism, especially dyslipidemia, has gained attention since it is closely related to various health disorders. Evidence that wild bitter melon (WBM), a natural herbal food, plays a regulatory function in lipid synthesis and accumulation has accumulated. In our study, we isolated 3β,7β,25-trihydroxycucurbita-5,23-dien-19-al (TCD) fraction of WBM leaf extract and established a dyslipidemia model to validate the effects of TCD on human adipocytes and zebrafish. After being treated with WBM, hypertrophy was inhibited in adipocytes, and lipid accumulation was diminished in zebrafish livers. In addition, lipogenic markers, including peroxisome-proliferator-activated receptor α (PPARα) and fatty acid synthase (FASN), significantly decreased when zebrafish were given WBM extract after they were given a high-fat diet. These findings explored the role of WBM in lipid metabolism and provided new insights into the pharmaceutic application of TCD in dyslipidemia.
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Wu et al. (2021) studied Dyslipidemia. 3β,7β,25-trihydroxycucurbita-5,23-dien-19-al (TCD) fraction of wild bitter melon leaf extract vs. High-fat diet without extract was evaluated on Lipid accumulation and lipogenic markers (PPARα and FASN). Wild bitter melon leaf extract (TCD fraction) inhibited adipocyte hypertrophy and diminished hepatic lipid accumulation and lipogenic markers in a zebrafish model of diet-induced dyslipidemia.
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