Key result
A genome-wide association study identified four loci (TEX41, FOXO1, C1orf21, and MRVI1) significantly associated with arterial stiffness index in 127,121 European-ancestry individuals.
Why the study?
Arterial stiffness index is predictive of cardiovascular disease and mortality, motivating interest in identifying genetic loci associated with it to better understand arterial stiffness development.
Observational (n=127,121)
Yes
Standardized Mean Difference: 0.029
p-value: p=5.3 × 10^-12
This large genome-wide association study identified four novel genetic loci (TEX41, FOXO1, C1orf21, MRVI1) associated with arterial stiffness index, highlighting potential new biological pathways involved in vascular stiffness.
No takes yet. Share an insight, caveat, or question.
These loci should not change practice; hypothesis-generating for vascular stiffness pathways and requires validation.
Fung et al. (2019) conducted an observational in Arterial stiffness (n=127,121). Genetic variants (SNVs) vs. Reference alleles was evaluated on Arterial stiffness index (ASI) (β = 0.029, p=5.3 × 10^-12). A genome-wide association study identified four loci (TEX41, FOXO1, C1orf21, and MRVI1) significantly associated with arterial stiffness index in 127,121 European-ancestry individuals.
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