Key result
The severity of nonalcoholic fatty liver disease on ultrasound was directly correlated with estimated cardiovascular risk using the Framingham Risk Score (Spearman rho 0.741, P = 0.009).
Why the study?
Does the severity of ultrasound-based NAFLD correlate with cardiometabolic risk and Framingham Risk Score in Filipino wellness patients?
Cross-Sectional (n=100)
No
Does the severity of ultrasound-based NAFLD correlate with cardiometabolic risk and Framingham Risk Score in Filipino wellness patients?
Effect estimate: Spearman rho 0.741
p-value: p=0.009
Ultrasound-based grading of NAFLD severity correlates with metabolic abnormalities and higher Framingham Risk Score, suggesting NAFLD is a marker for increased cardiovascular risk.
May support ultrasound NAFLD grading as CV risk marker in wellness cohorts; leaves open prospective validation beyond Framingham factors.
Introduction: Nonalcoholic fatty liver disease (NAFLD) is a prevalent condition which is known to be related to factors that predispose to the development of coronary artery disease as well as development of metabolic syndrome. The study aimed to determine the association between ultrasound-based grading of hepatic steatosis with metabolic profile and estimated cardiovascular risk using the Framingham Risk Score (FRS). Methods: This was a cross-sectional study on 100 Filipino patients without established cardiovascular disease who underwent a general wellness health evaluation. Cases with NAFLD diagnosed on the basis of ultrasound grading were analyzed. Comparison of demographics and metabolic parameters between grades of hepatic steatosis was performed using Kruskal Wallis test. FRS was used to assess cardiovascular risk with Spearman rank test for correlation with the degree of NAFLD. Results: Mean age was 47 ± 9.6 years, with 70% males. Mean body mass index (BMI) was 28.7 ± 5.1. Most patients had grade I NAFLD (53%), 34% were grade II, and 13% were grade III. BMI (P =0.034), liver enzymes (alanine aminotransferase [ALT], P = 0.001; aspartate aminotransferase [AST], P = 0.00), triglycerides (P = 0.047), and fasting blood sugar [FBS] (P = 0.049) were associated with fatty liver grade. No association was noted with total cholesterol (P = 0.569), high density lipoprotein (HDL) (P = 0.220), and low density lipoprotein (LDL) (P = 0.792). Using the FRS 43% were stratified as low (<10% risk), 45% as intermediate (10%-20% risk) and 12% as high risk (>20% risk). Severity of fatty liver was directly correlated with the FRS (Spearman rank 0.741, P = 0.009). Conclusion: Ultrasound-based grading of the severity of NAFLD is associated with abnormalities in the metabolic profile of patients. The FRS is correlated with increasing severity of NAFLD based on ultrasound. These findings suggest that the presence of NAFLD may be a marker for the presence of increased cardiovascular risk and may help identify patients who may benefit from more aggressive therapies to prevent development of adverse cardiovascular events.
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Cuenza et al. (2017) conducted a cross-sectional in Nonalcoholic fatty liver disease (NAFLD) (n=100). Severity of ultrasonographic nonalcoholic fatty liver disease was evaluated on Correlation between severity of fatty liver and Framingham Risk Score (FRS) (Spearman rho 0.741, p=0.009). The severity of nonalcoholic fatty liver disease on ultrasound was directly correlated with estimated cardiovascular risk using the Framingham Risk Score (Spearman rho 0.741, P = 0.009).
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