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Drug release from water-in oil-in water (w/o/w)multiple emulsions stabilized with colloidal microcrystal-line cellulose and various surface-active agents has been studied in vitro. Lidocaine hydrochloride and lidocaine base were used as model drugs for these studies. Drug concentrations were measured by HPLC, and effective diffusion coefficients were determined.
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Oza et al. (1989) studied this question.
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