Key result
Pulsed field ablation using a focal catheter achieved durable suppression or reduction in PVC burden without complications in 2 patients with treatment-refractory papillary muscle PVCs.
Why the study?
Radiofrequency ablation of papillary muscle premature ventricular contractions is challenging due to catheter instability and limited tissue penetration, resulting in limited clinical success.
Does pulsed field ablation (PFA) reduce PVC burden in patients with treatment-refractory papillary muscle PVCs?
Case Report (n=2)
Does pulsed field ablation (PFA) reduce PVC burden in patients with treatment-refractory papillary muscle PVCs?
Focal pulsed field ablation may offer a novel, effective approach for treating refractory papillary muscle PVCs by overcoming the limitations of radiofrequency ablation in fibrotic tissue.
Supports PFA feasibility for refractory papillary muscle PVCs; hypothesis-generating and requires prospective validation before practice change.
The papillary muscles are a common site of origin for premature ventricular contractions (PVCs). Radiofrequency ablation of these PVCs is often challenging due to catheter instability and the inability to penetrate fibrotic tissue, leading to limited clinical success in PVC suppression. In this report, we describe the use of pulsed field ablation (PFA), delivered via a novel focal ablation catheter, to successfully treat papillary muscle PVCs in 2 symptomatic, treatment-refractory patients. Both patients had previously undergone at least 1 failed ablation attempt using conventional radiofrequency catheters but achieved durable suppression or reduction in PVC burden after a limited number of PFA applications. Neither patient experienced complications related to the delivery of PFA energy. Although the safety and efficacy of PFA within the ventricle are still being explored, its rapid energy delivery and ability to penetrate fibrotic tissue may make it uniquely suited for ablation of PVCs originating from papillary muscles.
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Saleem et al. (2025) conducted a case report in Premature ventricular contractions (PVCs) from the papillary muscle (n=2). Pulsed field ablation (PFA) via a focal ablation catheter was evaluated on Suppression or reduction in PVC burden. Pulsed field ablation using a focal catheter achieved durable suppression or reduction in PVC burden without complications in 2 patients with treatment-refractory papillary muscle PVCs.
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