Chronic Hepatitis in Hemophilia

Editorial1 June 1977Chronic Hepatitis in HemophiliaLEONARD B. SEEFF, M.D., JAY HOOFNAGLE, M.D.LEONARD B. SEEFF, M.D.Search for more papers by this author, JAY HOOFNAGLE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-6-818 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPersons with hemophilia are at unusually high risk of developingacuteviral hepatitis as a result of their need for repeated treatment with blood products. Although less than one fourth of adult hemophiliac patients have a history of acute hepatitis, at least three fourths of them can be shown by serologic tests for the hepatitis B surface antigen (HBsAg) and antibody (antiHBs) to have been exposed to type B hepatitis (1). Some recent evidence has suggested thatchronichepatitis might also be common in this population (2), a consequence of treatment with blood products that might have been predicted. Prospective...References1. PETERSONBARKERSCHADE MLD: Detection of antibody to hepatitis-associated antigen in hemophilia patients and in voluntary blood donors. Vox Sang 24:66-75, 1973 CrossrefMedlineGoogle Scholar2. MANNUCCICAPITANIODEL NINNO PAE: Asymptomatic liver disease in hemophiliacs. J Clin Pathol 28:620-624, 1975 CrossrefMedlineGoogle Scholar3. SEEFFZIMMERMANWRIGHT LHE: A randomized, double-blind controlled trial of the efficacy of immune serum globulin for the prevention of post-transfusion hepatitis: a Veterans Administration cooperative study. Gastroenterology 72:111-121, 1977 CrossrefMedlineGoogle Scholar4. LEVINEMCVERRYSEGELMAN PBA: Comprehensive health care clinic for hemophiliacs. Arch Intern Med 136:792-794, 1976 CrossrefMedlineGoogle Scholar5. WEBSTERBLATTLESESNE WPH: Liver function tests in hemophiliacs, in Unresolved Therapeutic Problems in Hemophilia, edited by ARONSON DL, FRATANTONI J. Department of Health, Education, and Welfare publication no. (NIH) 77-1089. Bethesda, National Institute of Health, 1977, pp. 30-40 Google Scholar6. SEEFFZIMMERMANWRIGHT LHE: Hepatic disease in asymptomatic parenteral narcotic drug abusers: a Veterans Administration collaborative study. Am J Med Sci 270:41-47, 1975. CrossrefMedlineGoogle Scholar7. ALEDORT L: The cause of death in hemophiliacs, in Unresolved Therapeutic Problems in Hemophilia, edited by ARONSON DL, FRATANTONI J. Department of Health, Education, and Welfare publication no. (NIH) 77-1089. Bethesda, National Institute of Health, 1977 pp. 8-14 Google Scholar8. DUDLEYSCHEUERSHERLOCK FPS: Natural history of hepatitis-associated, antigen-positive, chronic liver disease. Lancet 2: 1388-1393, 1972 CrossrefMedlineGoogle Scholar9. SCHALMSUMMERSKILLGITNICK SWG: Contrasting features and responses to treatment of severe chronic active liver disease with and without hepatitis Bs antigen. Gut 17:781-786, 1976 CrossrefMedlineGoogle Scholar10. BERKJONESPLOTZ PEP: Corticosteriod therapy for chronic active hepatitis (editorial). Ann Intern Med 85:523-525, 1976 LinkGoogle Scholar11. SOLOWAYSUMMERSKILLBAGGENSTOSS RWA: Clinical, biochemical and histological remission of severe chronic active liver disease: a controlled study of treatments and early prognosis. Gastroenterology 63:820-833, 1972 CrossrefMedlineGoogle Scholar12. SUMMERSKILLKORMANAMMON WMH: Prednisone for chronic active liver disease: dose titration, standard dose, and combination with azathioprine compared. Gut 16:876-883, 1975 CrossrefMedlineGoogle Scholar13. BLUMBERGALTERVISNICH BHS: A "new" antigen in leukemia sera. JAMA 191:541-546, 1965 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Departments of Medicine Veterans Administration Hospital Georgetown University School of Medicine Washington, D.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClosing the circle: a thirty-year retrospective on the AIDS/blood epidemicPresence of human immunodeficiency virus (HIV) and T‐lymphotropic virus type I and II (HTLV‐I/II) in a Haemophiliac population in Belo Horizonte, Brazil, and correlation with additional serological resultsHaemophilia and AIDSLiver Disease and Pathology in HemophiliaEvidence that less replacement therapy is required for dental extractions in hemophiliacsdDAVP in von Willebrand’s Disease and in Moderately Severe Hemophilia AStörungen der HämostaseDDAVP: A useful alternative to blood components in moderate hemophilia A and von Willebrand diseaseAIDS and Preventive Treatment in HemophiliaImmune complexes in hemophiliaRecent advances in haematology.Blood Transfusion Therapy: Components, Indications, Complications and Controversies 1 June 1977Volume 86, Issue 6Page: 818-820KeywordsBloodChronic hepatitisHemophiliaHepatitis AHepatitis B surface antigen Issue Published: 1 June 1977 PDF downloadLoading ...