May 1, 2001Anesthesia & Analgesia

Rapacuronium: An Alternative To Succinylcholine For Electroconvulsive Therapy

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Why the study?

Does rapacuronium provide safe and effective muscle relaxation during ECT in a patient at risk for malignant hyperthermia?

Population

1 adult male hospitalized for major depression, scheduled for electroconvulsive therapy, with a family…

Design

Case_report

Follow-up

4 ECT sessions

Authors

AKAndrew G. KadarCedars-Sinai Medical Center BKBarry Alan KramerUniversity of Southern California PWPaul F. WhiteCedars-Sinai Medical Center

Discussion

Member takes

Implication

Rapacuronium may suit ECT muscle relaxation in select MH-risk cases; leaves open safety and efficacy pending controlled trials.

Structured PICO

Does rapacuronium provide safe and effective muscle relaxation during ECT in a patient at risk for malignant hyperthermia?

Population

1 adult male (51 years old, 96 kg, 178 cm) hospitalized for major depression, scheduled for electroconvulsive therapy (ECT), with a family history of malignant hyperthermia.

Intervention

Rapacuronium (60-75 mg IV) administered prior to ECT for muscle relaxation over 4 sessions.

Outcome

Adequacy of muscle relaxation during ECT and absence of malignant hyperthermia or postprocedural muscle pain.safety

Rapacuronium may be a safe and effective alternative to succinylcholine for muscle relaxation during ECT in patients at risk for malignant hyperthermia.

Limitations

Further studies are clearly needed to define the minimally effective dose of rapacuronium
The risk of cumulative effects with repeated administration during the acute phase of ECT is unknown
The optimal use of reversal drugs in this patient population needs further study

Cite This Study

Kadar et al. (2001) studied this question.

synapsesocial.com/papers/6a95c2128cd27757a8d037f7 https://doi.org/10.1097/00000539-200105000-00018

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Rapacuronium: An Alternative To Succinylcholine For Electroconvulsive Therapy

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Rapacuronium: An Alternative To Succinylcholine For Electroconvulsive Therapy

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider