Key result
Epicardial fat thickness was significantly higher in patients with CAD than controls (5.55 vs 3.25 mm, p<0.0001) and an EFT ≥ 4.75 mm predicted significant CAD with 87% sensitivity.
Why the study?
Epicardial fat thickness reflects visceral adiposity and is associated with CAD, but its correlation with CAD severity and its predictive cut-off needed assessment.
Does echocardiographic epicardial fat thickness correlate with the severity of coronary artery disease in patients undergoing coronary angiogram?
Observational (n=503)
Does echocardiographic epicardial fat thickness correlate with the severity of coronary artery disease in patients undergoing coronary angiogram?
Effect estimate: r = 0.906
Absolute Event Rate: 5.55% vs 3.25%
p-value: p=< 0.0001
Echocardiographic epicardial fat thickness strongly correlates with angiographic coronary artery disease severity and may serve as a non-invasive predictor of significant CAD.
Epicardial fat thickness (EFT) reflects visceral adiposity and is associated with coronary artery disease (CAD). This study aimed to assess the correlation of echocardiographic EFT with the severity of CAD and to determine the EFT cut-off to predict CAD. EFT was measured in 503 patients undergoing coronary angiogram. Mean EFT was significantly higher in the CAD group than control group (5.55 ± 1.21 mm vs 3.25 ± 1.15 mm, p < 0.0001). EFT correlated with Gensini score (r = 0.906, p < 0.001). EFT cut-off ≥ 4.75 mm had 87% sensitivity and 63% specificity for prediction of significant CAD (AUC: 0.831, p < 0.001).
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S et al. (2020) conducted an observational in Coronary artery disease (n=503). Epicardial fat thickness vs. Control group (patients without CAD) was evaluated on Mean epicardial fat thickness (EFT) and correlation with CAD severity (r = 0.906, p=< 0.0001). Epicardial fat thickness was significantly higher in patients with CAD than controls (5.55 vs 3.25 mm, p<0.0001) and an EFT ≥ 4.75 mm predicted significant CAD with 87% sensitivity.
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