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Mix it up a little bit: A diffusive nanomixer for single-molecule studies has been developed that allows single-molecule fluorescence studies to be performed under nonequilibrium conditions in free solution without compromising the signal-to-noise ratio. This method has been used for direct monitoring by single-molecule fluorescence resonance energy transfer of the conformations of a quadruplex during unfolding.
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White et al. (2006) studied this question.
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