Key result
Operation time >120 minutes (OR 10.69; 95% CI 3.95-28.94), ASA physical status ≥3, and intra-operative hypotension were significant risk factors for early post-operative stroke.
Why the study?
Most post-operative stroke cases occur within 24 hours, but the incidence, risk factors, and outcomes of early post-operative stroke after surgery required investigation.
What are the incidence, risk factors, and outcomes of early post-operative stroke within 24 hours after surgery?
Case-Control (n=284,105)
No
What are the incidence, risk factors, and outcomes of early post-operative stroke within 24 hours after surgery?
Early post-operative stroke is rare (0.015%) but associated with poor clinical outcomes, with key risk factors including high ASA status, prolonged surgery, and intra-operative hypotension.
Most post-operative stroke cases occur within 24 hours. This retrospective case-control study aimed to investigate the incidence, risk factors, and outcomes of early post-operative stroke that occurred within 24 hours after surgery in a university-based tertiary care hospital. Medical records were collected and reviewed between 2015 and 2021. Early post-operative stroke cases were compared with age-matched controls in a 1:3 ratio, and data regarding patient characteristics, intra-operative events, and post-operative outcomes were analyzed. Multiple logistic regression was performed to identify the risk factors for post-operative stroke. The incidence of early (≤24 hours) post-operative stroke was 0.015% (43 out of 284,105 cases). The multivariable analysis revealed that American Society of Anesthesiologists (ASA) physical status ≥3 (adjusted odds ratio [OR]: 3.12; 95% confidence interval [CI]: 1.22-7.99, P = .017), operation time >120 minutes (adjusted OR: 10.69; 95% CI: 3.95-28.94, P < .001), and intra-operative hypotension and inotrope/vasopressor use (adjusted OR: 2.80; 95% CI: 1.08-7.24, P = .034) were risk factors for early post-operative stroke. Compared to the controls, stroke patients had higher rates of planned and unplanned intensive care unit (ICU) admission, length of stay, ventilator use, and death. Despite its low incidence (0.015%), stroke is associated with poor clinical outcomes and increased mortality. Stratification of potential risks and establishment of risk optimization may help reduce stroke incidence.
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Somnuke et al. (2023) conducted a case-control in Early post-operative stroke (n=284,105). Operation time >120 minutes, ASA physical status ≥3, and intra-operative hypotension vs. Matched controls without early post-operative stroke was evaluated on Early post-operative stroke (OR 10.69, 95% CI 3.95-28.94, p=<.001). Operation time >120 minutes (OR 10.69; 95% CI 3.95-28.94), ASA physical status ≥3, and intra-operative hypotension were significant risk factors for early post-operative stroke.
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