Baker & Happold (1940) deduced from their evi- dence that the following structural conditions are essential for the breakdown of tryptophan to indole by the tryptophanase enzyme of Each. coli: (1) a free carboxyl group, (2) an unsubstituted ac-amino group, (3) a side-chain ,-carbon atom capable of oxidative attack. On the basis of these results a tentative scheme for the breakdown mechanism was suggested.
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Baker et al. (1946) studied this question.
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