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February 1, 2008JCR Journal of Clinical Rheumatology

HLA-B27 and Its Pathogenic Role

Muhammad Asim Khan

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Abstract

In Brief This reviews the fascinating complexities of the role of HLA-B27 in the spondylarthropathies.

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Muhammad Asim Khan (2008) studied this question.

synapsesocial.com/papers/6a95c9cbd12eefb5f339db3b https://doi.org/10.1097/rhu.0b013e3181637a38

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Diagnostic Value of HLA-B27 Testing in Ankylosing Spondylitis and Reiter's SyndromeOriginal Research · 1982 · 116 citations
2Update on SpondyloarthropathiesReview · 2002 · 519 citations
3Comparison of clinical features in HLA‐B27 positive and negative patients with ankylosing spondylitisOriginal Research · 1977 · 163 citations
4A locus on chromosome 9p predisposes to a specific disease manifestation, acute anterior uveitis, in ankylosing spondylitis, a genetically complex, multisystem, inflammatory diseaseOriginal Research · 2005 · 69 citations
5HLA—B27 Homozygosity in Ankylosing Spondylitis: Relationship to Risk and SeverityOriginal Research · 1978 · 61 citations

HLA–B27 up‐regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: Implications for the pathogenesis of spondylarthritis‐like disease2006
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