Key result
Metabolic syndrome defined by IDF criteria modified for Central Africa was the strongest independent determinant of Type 2 diabetes mellitus among Congolese bank employees (OR 56.8).
Cross-Sectional (n=126)
Odds Ratio: 56.8 (95% CI 16.4–103)
Absolute Event Rate: 90% vs 1.9%
p-value: p=<0.0001
There is a high prevalence of diabetes and pre-diabetes among Congolese bank employees, which is strongly associated with metabolic syndrome and abdominal obesity.
Supports targeted screening in Central African workers; leaves open prospective validation of modified IDF criteria for diabetes prediction.
Background: Aim: Congolese Bank employees are often inactive without valid information on the burden of dysglycemia and cardiometabolic risk. This study aims to assess the prevalence rates of diabetes mellitus (DM) and pre-diabetes and to identify the environmental, genetic and cardiometabolic risk factors associated with Type 2 diabetes mellitus (T2DM) and pre-diabetes among Congolese bank employees. Methods: In representative 126 bank employees from Brazzaville, Congo, Central Africa, Abdominal obesity, dyslipidemia and metabolic syndrome (MetS) were defined by IDF for Europe, NCEP-ATPIII and IDF criteria modified for Central Africa. Projected high 10-year total risk of coronary heart disease (CHD) ≥20% was calculated using Framingham scores. Results: Out of the employees, 16% and 21.4% had DM and pre-diabetes, respectively. The rate of T2DM among diabetics was estimated 90%. Aging, high total cholesterol, high LDL-cholesterol, high conicity index and longer urban residence after migration were significantly associated with pre-diabetes. Physical inactivity, smoking, excessive alcohol intake, abdominal obesity, female gender, low HDL-C, hypertension, CHD, projected high 10-year total CHD risk, age ≥ 55 years, urban residence, Southern area residence, high socioeconomic status, non married status, MetS/NCEP, MetS/IDF for Europe and MetS/IDF for Africa were significantly associated with T2DM.MetS/IDF for Africa was the only independent determinant of T2DM. Conclusion: Urgent prevention and intervention programme are needed to curb the alarming increase in DM, T2DM, pre-diabetes.
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Gombet et al. (2014) conducted a cross-sectional in Diabetes Mellitus and Pre-diabetes (n=126). Metabolic syndrome (IDF criteria for Central Africa) vs. No metabolic syndrome was evaluated on Type 2 Diabetes Mellitus (OR 56.8, 95% CI 16.4-103, p=<0.0001). Metabolic syndrome defined by IDF criteria modified for Central Africa was the strongest independent determinant of Type 2 diabetes mellitus among Congolese bank employees (OR 56.8).
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