Key result
Andrographolide dose-dependently suppressed cardiac inflammation, oxidative stress, and apoptosis, ameliorating cardiac fibrosis and hypertrophy in STZ-induced diabetic mice.
Why the study?
Does Andrographolide ameliorate myocardial dysfunction and diabetic cardiomyopathy in STZ-induced diabetic mice?
Population
STZ-induced diabetic mice and in vitro models
Design
Preclinical
Authors
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Hypothesis-generating for andrographolide in diabetic cardiomyopathy; human trials needed before clinical consideration.
Does Andrographolide ameliorate myocardial dysfunction and diabetic cardiomyopathy in STZ-induced diabetic mice?
Andrographolide demonstrates therapeutic potential for diabetic cardiomyopathy in preclinical models by attenuating oxidative stress, inflammation, and apoptosis.
Liang et al. (2018) studied diabetic cardiomyopathy. Andrographolide was evaluated on cardiac inflammation and oxidative stress. Andrographolide dose-dependently suppressed cardiac inflammation, oxidative stress, and apoptosis, ameliorating cardiac fibrosis and hypertrophy in STZ-induced diabetic mice.
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