Tolerance of Skin Homografts Induced in Adult Mice by Multiple Injections of Homologous Spleen Cells.

Adult mice of the Z(C3H) strain have been made tolerant of skin homo-grafts of the(A X Z) F1 hybrid strain by repeated intravenous and intraperitoneal injections of homologous spleen cells. 2. Repeated intraperitoneal injections of homologous spleen cells generally failed to induce a tolerant state, although 3/75 recipients accepted the homologous skin homotransplant.