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Reviews clinical features and translational progress in Hutchinson-Gilford progeria syndrome, highlighting cardiovascular decline as the primary cause of early mortality.
Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal genetic disorder that results in accelerated atherosclerosis and signs and symptoms of rapid aging. The incidence has been estimated at approximately 1 in 4 million births.1 Children with HGPS have failure to thrive, alopecia, thinning of skin, loss of body fat, headaches, atherosclerosis, cardiovascular disease, and stroke. Death occurs at an average age of 13 years and most commonly results from myocardial infarction or stroke.
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King et al. (2013) studied this question.
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