Key result
A single intranasal administration of hAT-MSC-derived extracellular vesicles 24 hours after ischemic stroke in rats reversed impairments in motor function, memory, and anxiety-like behavior.
Why the study?
Ischemic stroke is a major cause of death and disability requiring innovative therapies, making extracellular vesicles from mesenchymal stem cells promising candidates.
Does intranasal administration of hAT-MSC-derived EVs improve motor and behavioral recovery in a rat model of ischemic stroke?
Does intranasal administration of hAT-MSC-derived EVs improve motor and behavioral recovery in a rat model of ischemic stroke?
Intranasal administration of extracellular vesicles from human adipose stem cells promotes motor and cognitive recovery in a rat model of ischemic stroke.
Hypothesis-generating for intranasal EVs in stroke recovery; leaves open translation pending larger preclinical and human studies.
Ischemic stroke is a prominent cause of death and disability, demanding innovative therapeutic strategies. Accordingly, extracellular vesicles (EVs) released from mesenchymal stem cells are promising tools for stroke treatment. In this study, we evaluated the potential neuroprotective properties of EVs released from human adipose tissue stem cells (hAT-MSC), which were obtained from a healthy individual submitted to liposuction. A single intranasal EVs administration was performed 24 h after the ischemic stroke in rats. The EVs brain penetration and the tropism to brain zone of ischemia was observed 18 h after administration. Thus, we measured EVs neuroprotection against the ischemic stroke-induced impairment on long-term motor and behavioral performance. Indeed, one single intranasal EVs administration reversed the stroke damages on: i) front paws symmetry; ii) working memory, short- and long-term memory; iii) anxiety-like behavior. These findings highlight hAT-MSC-derived EVs as a promising therapeutic strategy in stroke.
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Rohden et al. (2020) studied Ischemic stroke. Extracellular vesicles from human adipose tissue mesenchymal stem cells (hAT-MSC-derived EVs) vs. PBS (vehicle) was evaluated on Motor function (front paws symmetry), working memory, short- and long-term memory, and anxiety-like behavior. A single intranasal administration of hAT-MSC-derived extracellular vesicles 24 hours after ischemic stroke in rats reversed impairments in motor function, memory, and anxiety-like behavior.
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