Key result
The minor alleles of PCSK1 SNPs rs6232 and rs6235 were associated with elevated glucose-stimulated proinsulin conversion, and rs6232 was additionally associated with 15% higher insulin sensitivity.
Why the study?
Do common obesity risk SNPs in the PCSK1 gene (rs6232 and rs6235) influence insulin sensitivity and proinsulin conversion in non-diabetic subjects?
Population
1,498 non-diabetic subjects from southwestern Germany with an increased risk for type 2 diabetes mellitus.
Comparison
Presence of minor alleles for PCSK1 single… vs Homozygous carriers of the major alleles for…
Design
Cross-sectional
Authors
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No immediate clinical implications; hypothesis-generating for PCSK1 variants in glucose metabolism and requires prospective validation.
Cross-Sectional (n=1,498)
Do common obesity risk SNPs in the PCSK1 gene (rs6232 and rs6235) influence insulin sensitivity and proinsulin conversion in non-diabetic subjects?
Effect estimate: 21% higher for rs6232
p-value: p=≤0.01
Common genetic variants in the PCSK1 gene (rs6232 and rs6235) are associated with altered glucose-stimulated proinsulin conversion, and rs6232 is independently associated with increased insulin sensitivity.
Heni et al. (2010) conducted a cross-sectional in Non-diabetic subjects (prediabetic traits) (n=1,498). PCSK1 SNPs rs6232 and rs6235 vs. Major allele carriers was evaluated on Proinsulin-to-insulin conversion (AUCproinsulin/AUCinsulin) (21% higher for rs6232, p=≤0.01). The minor alleles of PCSK1 SNPs rs6232 and rs6235 were associated with elevated glucose-stimulated proinsulin conversion, and rs6232 was additionally associated with 15% higher insulin sensitivity.
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