Key result
The combination of electroconvulsive therapy and the serotonin and noradrenaline re-uptake inhibitor venlafaxine resulted in a case of prolonged hypertension.
Case Report (n=1)
The combination of electroconvulsive therapy and venlafaxine may result in potentially serious cardiovascular complications such as prolonged hypertension.
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May indicate risk of prolonged hypertension with ECT plus venlafaxine; hypothesis-generating and requires confirmation.
Electroconvulsive therapy is often given in addition to antidepressant drugs when there has been an inadequate response to the latter. In the case of tricyclic antidepressants and monoamine oxidase inhibitors, this is not regarded as a hazardous combination. Caution is however advised with selective serotonin re-uptake inhibitors, since there may be a prolongation of seizures. Cardiovascular complications resulting from the combination of ECT and antidepressant medication have not been previously reported. We report on a case of prolonged hypertension following ECT in a patient taking the serotonin and noradrenaline re-uptake inhibitor, venlafaxine. Possible mechanisms for this potentially very serious interaction are discussed.
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West et al. (1999) conducted a case report in Prolonged hypertension (n=1). Electroconvulsive therapy and venlafaxine combination was evaluated on Prolonged hypertension. The combination of electroconvulsive therapy and the serotonin and noradrenaline re-uptake inhibitor venlafaxine resulted in a case of prolonged hypertension.
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