Hepatitis B Virus (HBV) could also be a noncytopathic DNA virus that infects approximately 350 million people worldwide and should be a number one explanation for liver cirrhosis and hepatoma. The evolutionary dynamics of HBV are characterized by high mutation rates due to the error-prone polymerase (RT) and rapid replication rates. Thus, an outsized number of viral variants are constantly generated, creating great genetic diversity on which survival operates.
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