Key result
In non-valvular atrial fibrillation, over 90% of thrombus formation occurs in the left atrial appendage, making its closure a rational target to prevent stroke.
Why the study?
In non-valvular atrial fibrillation, over 90% of thrombi form in the left atrial appendage, providing a rationale for therapies targeting the appendage to prevent cardio-embolic stroke.
Left atrial appendage closure targets the primary source of thrombus in non-valvular atrial fibrillation to prevent cardio-embolic stroke.
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Supports LAA closure rationale in NVAF; leaves open comparative effectiveness versus contemporary anticoagulation.
Benedetto Massimo (2021) conducted a review in Atrial fibrillation. Left atrial appendage closure was evaluated. In non-valvular atrial fibrillation, over 90% of thrombus formation occurs in the left atrial appendage, making its closure a rational target to prevent stroke.
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