What question did this study set out to answer?

To determine the temporal and spatial distribution of Clara cell-specific protein and its mRNA in the developing human respiratory tract and in neonatal lung disease.

December 1, 1996Journal of Histochemistry & Cytochemistry

Ontogeny of Clara cell-specific protein and its mRNA: their association with neuroepithelial bodies in human fetal lung and in bronchopulmonary dysplasia.

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Authors

AKAndrás KhoórJacksonville College MGMary E. GrayCincinnati Children's Hospital Medical Center GSGurmukh SinghAugusta University

Discussion

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Implication

Observational study reveals early Clara cell-specific protein localization near neuroepithelial bodies in human fetal lungs, suggesting shared epithelial lineages and regenerative roles.

Key Points

To determine the temporal and spatial distribution of Clara cell-specific protein and its mRNA in the developing human respiratory tract and in neonatal lung disease.
Examined human fetal tissues spanning 12 to 23 weeks of gestation and infant lung specimens with and without bronchopulmonary dysplasia.
Mapped protein and gene expression patterns across tracheal, bronchial, and bronchiolar epithelia using immunohistochemistry and in situ hybridization.
Clara cell-specific protein immunoreactivity emerged in bronchiolar epithelial cells at 12 weeks of gestation, followed by bronchial cells at 14 weeks and tracheal cells at 15 weeks.
Clara cell-specific mRNA was detected in bronchial and bronchiolar epithelia from 16 weeks onward and in tracheal tissue between 19 and 23 weeks of gestation.
Clara cell-specific protein- and mRNA-positive epithelial cells formed distinct clusters around neuroepithelial bodies at airway branch points, with subsets of cells co-expressing surfactant proteins.

Cite This Study

Khoór et al. (1996) studied this question.

synapsesocial.com/papers/6a95d14e35ce0ca9f8250440 https://doi.org/10.1177/44.12.8985135

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December 1, 1996Journal of Histochemistry & Cytochemistry

Ontogeny of Clara cell-specific protein and its mRNA: their association with neuroepithelial bodies in human fetal lung and in bronchopulmonary dysplasia.

View Full Paper

Ask AI

Bookmark

Authors

AKAndrás KhoórJacksonville College MGMary E. GrayCincinnati Children's Hospital Medical Center GSGurmukh SinghAugusta University

Discussion

Member takes

Implication

Observational study reveals early Clara cell-specific protein localization near neuroepithelial bodies in human fetal lungs, suggesting shared epithelial lineages and regenerative roles.

Key Points

To determine the temporal and spatial distribution of Clara cell-specific protein and its mRNA in the developing human respiratory tract and in neonatal lung disease.
Examined human fetal tissues spanning 12 to 23 weeks of gestation and infant lung specimens with and without bronchopulmonary dysplasia.
Mapped protein and gene expression patterns across tracheal, bronchial, and bronchiolar epithelia using immunohistochemistry and in situ hybridization.
Clara cell-specific protein immunoreactivity emerged in bronchiolar epithelial cells at 12 weeks of gestation, followed by bronchial cells at 14 weeks and tracheal cells at 15 weeks.
Clara cell-specific mRNA was detected in bronchial and bronchiolar epithelia from 16 weeks onward and in tracheal tissue between 19 and 23 weeks of gestation.
Clara cell-specific protein- and mRNA-positive epithelial cells formed distinct clusters around neuroepithelial bodies at airway branch points, with subsets of cells co-expressing surfactant proteins.

Cite This Study

Khoór et al. (1996) studied this question.

synapsesocial.com/papers/6a95d14e35ce0ca9f8250440 https://doi.org/10.1177/44.12.8985135

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