Key result
Serious bleeding events after transcatheter aortic valve implantation independently predicted increased 1-year all-cause mortality (HR 5.88) compared to patients without such events.
Why the study?
What is the incidence, predictors, and impact of severe periprocedural bleeding according to VARC-2 criteria on 1-year clinical outcomes in patients after TAVI?
Population
129 consecutive patients with severe aortic stenosis who underwent TAVI, median age 79.1 ± 8.3 years, 48%…
Design
Cohort
Follow-up
1 year (mean 13.1 ± 2.9 months)
Authors
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Serious bleeding after TAVI warrants heightened prevention efforts; leaves open whether mitigation improves survival.
Cohort (n=129)
No
What is the incidence, predictors, and impact of severe periprocedural bleeding according to VARC-2 criteria on 1-year clinical outcomes in patients after TAVI?
Hazard Ratio: 5.88 (95% CI 1.73–19.94)
Absolute Event Rate: 40% vs 11.1%
p-value: p=0.005
Severe periprocedural bleeding events according to VARC-2 criteria are frequent after TAVI and independently predict increased 1-year all-cause mortality.
Kochman et al. (2015) conducted a cohort in Severe aortic stenosis (n=129). Serious bleeding events (VARC-2 life-threatening/disabling or major bleeding) vs. No serious bleeding events was evaluated on 1-year all-cause mortality (HR 5.88, 95% CI 1.73-19.94, p=0.005). Serious bleeding events after transcatheter aortic valve implantation independently predicted increased 1-year all-cause mortality (HR 5.88) compared to patients without such events.
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