Key result
Hybrid ablation showed no significant difference in overall freedom from atrial arrhythmia compared to transcatheter ablation (OR 2.10), but significantly increased the risk of procedural adverse events.
Why the study?
Despite successful lesion sets during hybrid ablation, AF recurrence, atrial arrhythmia, and procedural complications still occur, warranting a comparison of efficacy and safety between hybrid ablation and transcatheter ablation.
Does hybrid ablation improve freedom from atrial arrhythmia compared to transcatheter ablation in patients with persistent or long-standing persistent atrial fibrillation?
Meta-Analysis (n=331)
Does hybrid ablation improve freedom from atrial arrhythmia compared to transcatheter ablation in patients with persistent or long-standing persistent atrial fibrillation?
Odds Ratio: 2.1 (95% CI 0.45–9.88)
Hybrid ablation via mini-thoracotomy improves freedom from atrial arrhythmia in patients with persistent atrial fibrillation compared to transcatheter ablation, but is associated with a higher risk of procedural complications.
Authors
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Hybrid ablation confers no arrhythmia freedom benefit yet increases procedural risks; challenges its adoption and supports transcatheter ablation as preferred in persistent AF.
Zhang et al. (2019) conducted a meta-analysis in Atrial fibrillation (n=331). Hybrid ablation vs. Transcatheter ablation was evaluated on Freedom of atrial arrhythmia after follow-up duration (OR 2.10, 95% CI 0.45-9.88). Hybrid ablation showed no significant difference in overall freedom from atrial arrhythmia compared to transcatheter ablation (OR 2.10), but significantly increased the risk of procedural adverse events.
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