Key result
The Hitchner-B1/Massachusetts H120 vaccine produced a significantly higher peak antibody mean titer at 5 weeks of age compared to the B1/Massachusetts B-41 vaccine (11,544.43 vs 10,222.11, p<0.01).
Why the study?
Infectious bronchitis is a devastating infectious disease of poultry, motivating the determination of maternally derived antibody titers and comparison of two infectious bronchitis vaccines in layers.
Does the Hitchner-B1/H120 vaccine improve antibody titer compared to the B1/B-41 vaccine in layer birds?
RCT (n=1,600)
Equally allocated
No
Does the Hitchner-B1/H120 vaccine improve antibody titer compared to the B1/B-41 vaccine in layer birds?
Absolute Event Rate: 11544.43% vs 10222.11%
p-value: p=<0.01
Both infectious bronchitis vaccines produced protective antibody titers, with the Hitchner-B1/H120 strain vaccine generating a significantly higher peak titer at 5 weeks of age.
May guide IB vaccine strain selection in layers; leaves open field efficacy validation.
The infectious bronchitis (IB) is divesting infectious diseases of poultry. Hence, this study determined the maternally derived antibody (MDA) titer of IBV and comparison of two IB vaccine in layer. A total of 1600 birds were equally allocated into two groups (group-A and group-B). The group-A and group-B were vaccinated by two different vaccines having the strain “B1-Strain of ND+Massachusetts B-41 Strains of IBV” and “Hitchner-B1 Strain of ND+Massachusetts H120 Strains of IBV” respectively. Blood samples were collected and antibody titer was detected by indirect ELISA test. Results showed that both groups had the protective level of MDA titer and both the vaccines significantly (p<0.01) increased the antibody mean titer than the MDA. Between the groups, the highest antibody mean titer (11544.43±177.51) was observed in group-B at 5 weeks age and had significant (p<0.01) difference with group-A (10222.11±96.96). The effect size of the antibody titer was higher in group-B (14.25; CI: 9173.82-9564.39; n=46 at 5 weeks birds) than group-A (9.54; CI: 8580.19-9131.68; n=46 at one-day-old birds) respectively. Shortly, the MDA mean titer was in protective condition and both the IB vaccinated groups had the significantly (p<0.05) higher antibody mean titer than the protective level of antibody titer (>853).
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Meher et al. (2022) conducted an RCT in Infectious Bronchitis Virus (IBV) Immunity (n=1,600). Hitchner-B1 Strain of ND+Massachusetts H120 Strains of IBV vaccine vs. B1-Strain of ND+Massachusetts B-41 Strains of IBV vaccine was evaluated on Antibody mean titer at 5 weeks of age (p=<0.01). The Hitchner-B1/Massachusetts H120 vaccine produced a significantly higher peak antibody mean titer at 5 weeks of age compared to the B1/Massachusetts B-41 vaccine (11,544.43 vs 10,222.11, p<0.01).
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