Relationship between signal-averaged electrocardiography and dangerous ventricular arrhythmias in patients with left ventricular aneurysm after myocardial infarction

We performed signal-averaged electrocardiography (SAECG) and Holter monitoring, and subsequently followed-up 53 ambulatory patients with left ventricular aneurysm (LVA) after myocardial infarction (MI). A history of spontaneous episodes of sustained ventricular tachycardia (VT) was also analysed. Out of 53 patients, 25 (47%) had an abnormal SAECG. Abnormal SAECG correctly identified nine out of 10 cases with a history of sustained VT. Complex ventricular arrhythmias were detected on Holter monitoring in 23 patients: in five out of 28 with normal SAECG (18%) and in 18 out of 25 with abnormal SAECG (72%) (P less than 0.001). During follow-up (mean 19 months) sustained VT and/or sudden cardiac death (SCD) occurred in eight cases, out of which seven had an abnormal SAECG. The negative predictive value of SAECG (no VT or SCD during follow-up) was very high, 96%, similar to the negative predictive value of a history of sustained VT (93%). Using multivariate analysis only a history of sustained VT was an independent factor in predicting the outcome of patients in this study. We conclude that an abnormal SAECG identifies those post infarction patients with LVA who are prone to complex ventricular arrhythmias. A normal SAECG and an absence of a history of sustained VT strongly indicate that the risk of developing arrhythmic events is very low.