Why the study?
Does surgical treatment improve survival compared to medical treatment in patients with left ventricular aneurysm?
Does surgical treatment improve survival compared to medical treatment in patients with left ventricular aneurysm?
The survival benefit of surgical resection for left ventricular aneurysm remains controversial, with prospective data showing benefit primarily in high-risk subgroups with multivessel disease and angina.
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Questions routine surgical resection for LV aneurysm; challenges observational estimates and leaves open benefit in high-risk subgroups.
The prognosis for the patient with a left-ventricular aneurysm depends on the size of the aneurysm and the function of the remaining ventricle. Data in the literature suggest a 5-year-survival rate of 70-75% and a hospital mortality rate of 10% for aneurysmectomy with and without any additional aortocoronary bypass surgery. Medical treatment on the other hand is only credited with a markedly lower 5-year-survival rate of 45%. To date the only prospective data have been derived by the CASS Study, where no significant difference (67% for medical treatment, 69% for surgical treatment) was seen in the six-year-survival rate. However, considering only the patients with the combination of 3-vessel disease, coronary insufficiency, angina pectoris, and high age, the survival time after surgical treatment was significantly higher. The indication quoted for aneurysmectomy was angina pectoris in 46% of cases, acute or chronic coronary insufficiency in 33%, ventricular arrhythmias in 14%, and left ventricular thrombi in only 2.5%. The relative value of operative resection among the possible methods of treatment of the ventricular aneurysm is still a matter of controversy: there is a lack of larger-scale prospective studies comparing medical and surgical therapy.
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Tebbe et al. (1989) studied this question.
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