Population
Mice and guinea pigs (peritoneal exudate cells, spleen cells) and ME cells
Comparison
Mouse adenovirus (M-Ad) infection vs SV40 systems or uninfected controls
Design
Preclinical
Follow-up
Up to 20+ days post-infection
Authors
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Animal data on transient adenovirus-specific T-cell immunity leave open human relevance; prospective studies needed before clinical translation.
Cell-mediated immunity to mouse adenovirus is detectable by macrophage migration inhibition, peaks at 10 days post-infection, and is mediated by T cells responding to S antigen(s).
Inada et al. (1978) studied this question.
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