Key result
VILIP-2 binds to the CBD and IQ-like domains of CaV2.1 channels, slowing inactivation and enhancing facilitation during extended trains of stimuli.
VILIP-2 differentially regulates CaV2.1 channels by slowing inactivation and enhancing facilitation, which may be an important determinant of Ca2+ entry in neurotransmission.
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May shape presynaptic Ca2+ entry during repetitive firing; leaves open relevance to human synaptic disorders.
Lautermilch et al. (2005) studied this question. VILIP-2 coexpression vs. CaV2.1 channels alone was evaluated on CaV2.1 channel inactivation and facilitation. VILIP-2 binds to the CBD and IQ-like domains of CaV2.1 channels, slowing inactivation and enhancing facilitation during extended trains of stimuli.
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