Key result
Enteroviruses were identified in 66% (37 of 56) of fecal specimens from captive primates, revealing three known simian serotypes and two novel types (EV92 and EV103), with no human viruses detected.
Cross-Sectional (n=56)
No
The study identified both known and novel simian enteroviruses, but no human enteroviruses, in captive primates with diarrheal disease.
No human enteroviruses detected in primates suggests limited current zoonotic risk; leaves open pathogenicity and emergence potential of novel simian types.
In a recent study, we investigated cases of diarrheal disease among monkeys at a U.S. primate center. In that study, enteroviruses were detected in a high proportion of the fecal specimens tested. To determine whether the enterovirus detections represented the circulation of one or more simian enteroviruses within the colony or the transmission of human enteroviruses from animal handlers, we determined in the present study the serotype identity of each virus by reverse transcription-PCR and sequencing of a portion of the VP1 gene, a region whose sequence corresponds to antigenic type. Enteroviruses were identified in 37 of 56 specimens (66%), 30 of 40 rhesus macaques, 5 of 11 pigtail macaques, 2 of 4 sooty mangabeys, and 0 of 1 chimpanzee. No previously known human viruses were detected. Three previously known simian enterovirus serotypes--SV6, SV19, and SV46--were among the viruses identified, but more than half of the identified viruses were previously unknown; these have been assigned as new types: EV92 and EV103.
No takes yet. Share an insight, caveat, or question.
Nix et al. (2008) conducted a cross-sectional in Diarrheal disease (n=56). Natural enterovirus infection was evaluated on Detection and serotype identification of enteroviruses in fecal specimens. Enteroviruses were identified in 66% (37 of 56) of fecal specimens from captive primates, revealing three known simian serotypes and two novel types (EV92 and EV103), with no human viruses detected.