Case-Control (n=72)
No
Odds Ratio: 18 (95% CI 4–78)
Absolute Event Rate: 92% vs 38%
p-value: p=0.0001
In overweight patients, non-alcoholic fatty liver disease is significantly associated with central adiposity and insulin resistance, but not with differences in calorie intake or physical activity compared to healthy controls.
May support insulin resistance screening in overweight NAFLD patients; leaves open causal role and need for prospective confirmation.
Non alcoholic fatty liver disease (NAFLD) is associated with obesity, diabetes and insulin resistance (IR). The aim of our study was to assess the relationship between IR, anthropometry, lifestyle habits, resting energy expenditure (REE) and degree of fatty liver at ultrasound in 48 overweight patients with NAFLD as compared to 24 controls without fatty liver, matched for age. Nutritional status, alcohol intake and physical activity were assessed by skinfold thickness measurements, a 7-day diary, and SenseWear armband (SWA). REE was assessed by both SWA (REE-SWA) and a Vmax metabolic cart (REEVmax). Fatty liver was measured by US and the Doppler Power Index was calculated. IR was assessed using the HOMA index. There was significant correlation between waist circumference, HOMA, Doppler power index and fatty liver grade at US. Multivariate analysis showed that alteration of waist circumference, Doppler power index, and HOMA were the major significant predictors of fatty liver. Our data demonstrated a significant association between NAFLD and central adiposity and IR.
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Marcella Malavolti (2012) conducted a case-control in Non-alcoholic fatty liver disease (NAFLD) (n=72). High HOMA index (>0.9 in males, >1.2 in females) vs. Normal HOMA index was evaluated on Presence of NAFLD (OR 18, 95% CI 4-78, p=0.0001).
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