What question did this study set out to answer?

To characterize the clinical presentation, imaging findings, and longitudinal natural history of intraneural perineurioma to determine optimal management.

June 30, 2009BrainOpen Access

Longitudinal study of intraneural perineurioma--a benign, focal hypertrophic neuropathy of youth

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Authors

MMMichelle L. MauermannMayo Clinic KAKimberly K. AmramiMayo Clinic NKNancy L. KuntzNorthwestern University

Discussion

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Implication

Longitudinal study demonstrates slow progression and focal motor deficits in intraneural perineurioma, suggesting routine surgical resection is unnecessary.

Key Points

To characterize the clinical presentation, imaging findings, and longitudinal natural history of intraneural perineurioma to determine optimal management.
Longitudinal evaluation of 32 patients (16 children, 16 adults; median onset age 14 years) with pathologically confirmed intraneural perineurioma via targeted fascicular biopsy.
Diagnostic workup included MRI assessment of nerve lesions and baseline clinical quantification using the Neuropathy Impairment Score (NIS).
Patients underwent longitudinal monitoring via telephone follow-up (n=23; median duration 36 months, range 2–177 months) and formal neurologic reassessment (n=12; median 45 months, range 10–247 months).
All 32 patients presented with motor deficits and focal nerve lesions (27 mononeuropathies, 5 plexopathies; 15 sciatic nerve), while 27 experienced mild sensory symptoms or signs.
MRI showed nerve enlargement in 29/32, T1 isointensity in 27/32, T2 hyperintensity in 25/32, and contrast enhancement in 20/20 patients.
Neurologic impairment remained stable across follow-up, with median NIS shifting nonsignificantly from 12.6 to 15.4 points (P = 0.19) and the anatomical distribution of deficits remaining unchanged in all cases.

Cite This Study

Mauermann et al. (2009) studied this question.

synapsesocial.com/papers/6a95da4b2259ab2500e6ce10 https://doi.org/10.1093/brain/awp169

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Implication

Longitudinal study demonstrates slow progression and focal motor deficits in intraneural perineurioma, suggesting routine surgical resection is unnecessary.

Longitudinal study of intraneural perineurioma--a benign, focal hypertrophic neuropathy of youth

Discussion

Member takes

Implication

Key Points

Cite This Study

Longitudinal study of intraneural perineurioma--a benign, focal hypertrophic neuropathy of youth

Discussion

Member takes

Implication

Key Points

Cite This Study

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